connecting you to a world of zebrafish revertible mutants

connecting you to a world of zebrafish revertible mutants

A window to the heart:can zebrafish mutants help us

Oct 01, 2002 · The 42 heart-function mutations in zebrafish are broadly classified into two groups:those that affect contractility and those that affect rhythmicity ().All of the mutations are autosomal recessive and, with two exceptions [slow mo (smo) and weak atrium (wea)], they are all lethal in the early larval stage .The contractility mutants comprise the largest group of heart mutants, and their

Analysis of the zebrafish smoothened mutant reveals

RESULTS Identification of smo mutants and characterization of the smo gene. In an ongoing large-scale insertional mutagenesis screen (Amsterdam et al., 1999), we found two insertional mutant alleles in the zebrafish smo gene.One was found in F 2 family 229, the other in family 1640. We named the mutant smo, and the two alleles smo hi229 and smo hi1640, according to the Zebrafish Nomenclature Andrew PETZOLD Professor (Assistant) PhD University The attributes of the zebrafish (Danio rerio) make it an excellent model system for the development and discovery of new drugs. Connecting you to a world of zebrafish revertible mutants

Andrew Petzold - Google Scholar

Gene-breaking mutagenesis in zebrafish identifies the novel epidermal mutant wicked witch of the Midwest SE Westcot, D Balciunas, S Sivasubbu, KJ Clark, AM Petzold, G Moulder, JOURNAL OF INVESTIGATIVE DERMATOLOGY 130, S95-S95 , 2010 Connecting you to a world of zebrafish revertible mutants Connecting you to a world of zebrafish revertible mutants. Home; Lines. MN0001 to MN1000. MN0001 to MN0100. MN0001 to MN0010. We are using gene-breaking transposons to create dominantly labeled mutants in zebrafish (Sivasubbu et al., Mech Dev 2006, (2012) "zfishbook:connecting you to a world of zebrafish revertible mutants" Clark

Connecting you to a world of zebrafish revertible mutants

The following comments are owned by whomever posted them. This site is not responsible for what they say. David ARGUE Mayo Foundation for Medical Education and zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio.

David ARGUE Mayo Foundation for Medical Education and

zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. FAIRsharing:biodbcore-000108:zfishbookzfishbook:connecting you to a world of zebrafish revertible mutants. Clark KJ,Argue DP,Petzold AM,Ekker SC Nucleic Acids Res 2011 View Paper (PubMed) View Publication

FAIRsharing:biodbcore-000108:zfishbook

zfishbook:connecting you to a world of zebrafish revertible mutants. Clark KJ,Argue DP,Petzold AM,Ekker SC Nucleic Acids Res 2011 View Paper (PubMed) View Publication Faculty Research University of Minnesota RochesterConnecting analytics and curriculum design:The process and outcome of building a tool to browse data relevant to course designers. Journal of Learning Analytics. 1(3):220-240. zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic Acids Research. 40(Database issue):D907-11. Epub 2011 Nov 8.

Forward Genetic Screening Using Behavioral Tests in

The zebrafish enjoys several advantages over other model organisms. It is small, easy to maintain, prolific, and numerous genetic tools are available for it. For example, forward genetic screens have allowed investigators to identify important genes potentially involved in a variety of functions from embryogenesis to cancer. However, despite its sophisticated behavioral repertoire, behavioral GBT0435 - zfishbookAnnotated Zebrafish Anatomical Ontology (ZFA) Eion Tags:coelom, immune system, kidney, renal system, trunk Maternal mRFP:Known Phenotypes:Viability:

GBT0435 - zfishbook

Annotated Zebrafish Anatomical Ontology (ZFA) Eion Tags:coelom, immune system, kidney, renal system, trunk Maternal mRFP:Known Phenotypes:Viability: International Zebrafish Mutagenic Protein Trap - Stephen Clark, Karl J; Argue, David P; Petzold, Andrew M et al. (2012) zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic Acids Res 40:D907-11 Comments

International Zebrafish Mutagenic Protein Trap - Stephen

Ding, Yonghe; Liu, Weibin; Deng, Yun et al. (2013) Trapping cardiac recessive mutants via eion-based insertional mutagenesis screening. Circ Res 112:606-17 Clark, Karl J; Argue, David P; Petzold, Andrew M et al. (2012) zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic Acids Res 40:D907-11 International Zebrafish Mutagenic Protein Trap - Stephen EkkerThis proposal is to complete this molecularly characterized collection, in silico catalog and distribution network of revertible mutations for the preeminent non-mammalian vertebrate, the zebrafish. These dominantly marked mutants lines also represent an ideal substrate for large-scale behavioral and other phenotypic assessment of the genome as a part of the broader initiative to functionally annotate the vertebrate genome using the zebrafish.

Learning to Fish with Genetics:A Primer on the Vertebrate

Jul 01, 2016 · Box 1:golden mutants and skin pigmentation. An unexpected connection between zebrafish and human genetics came from study of the golden mutant, identified by Streisinger et al., which lacks pigmentation in the skin.Keith Chengs laboratory and collaborators found that a mutation in the slc24a gene, which encodes a cation exchanger important for Ca 2+ cycling (Altimimi and Protein-Trap Insertional Mutagenesis Uncovers New Genes zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic acids research. 2012; 40 (Database issue):D90711. doi:10.1093/nar/gkr957; PubMed Central PMCID:PMCPMC3245101. [PMC free article]

Shifting Zebrafish Lethal Skeletal Mutant Penetrance by

Request PDF Shifting Zebrafish Lethal Skeletal Mutant Penetrance by Progeny Testing Zebrafish mutant phenotypes are often incompletely penetrant, only manifesting in some mutants. Interesting Tagged Genes - zfishbookfc85b05, gli2, wu:fc85b05, yot, you-too (GenBank) Confirmed GBT0591:100009635 dhx37 (GenBank) 2013-08-21 fd11d06, im:7151586, wu:fd11d06, zgc:158802 (GenBank) Confirmed GBT0237:100006951 nrg2a (internal) nrg2a (GenBank) 2013-07-30 zgc:162973 (GenBank) Confirmed

The Zebrafish CreZoo:An Easy-to-Handle Database for

zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. Trapping Cardiac Recessive Mutants via Eion-Based Rationale:Mutagenesis screening is a powerful genetic tool for probing biological mechanisms underlying vertebrate development and human diseases. However, the increased colony management efforts i

Trapping Cardiac Recessive Mutants via Eion-based

The first two large-scale mutagenesis screens using ENU as a mutagen generated hundreds of mutants, which laid the foundation for the zebrafish to become a premier animal model. 8, 10 To address the limitations of molecular cloning, mutagens with a sequence tag have been exploited, including either retrovirus- 9, 11 or transposon-based vectors User Tutorials - zfishbookZebrafish Lines or GBT lines On zfishbook, zebrafish lines have been given a unique gene-break transposon (GBT) number. Each GBT line has its own line summary page. You can get to a summary page by selecting a line from the "Lines" menu or jumping to a line number. At the top of the summary page is a summary of information known for each line.

ZFIN Lab:Stephen C. Ekker Laboratory - ZFIN The Zebrafish

In parallel, we engineered transposon tools for the zebrafish including protein trap gene-breaking vectors to generate a collection of molecularly characterized and revertible mutant zebrafish lines, an ongoing effort in the laboratory. Custom restriction endonucleases offer a third leg, targeted genetic modification. ZFIN Person:Ekker, Stephen C. - Zebrafish Information In parallel, we engineered transposon tools for the zebrafish including protein trap gene-breaking vectors to generate a collection of molecularly characterized and revertible mutant zebrafish lines, an ongoing effort in the laboratory. Custom restriction endonucleases offer a third leg, targeted genetic modification.

ZFIN Person:Ekker, Stephen C. - Zebrafish Information

In parallel, we engineered transposon tools for the zebrafish including protein trap gene-breaking vectors to generate a collection of molecularly characterized and revertible mutant zebrafish lines, an ongoing effort in the laboratory. Custom restriction endonucleases offer a third leg, targeted genetic modification. Zebrafish Behavioral Models of Ageing SpringerLinkClark KJ, Argue DP, Petzold AM, Ekker SC. zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic Acids Res. 2012;40(D1):D90711. doi:10.1093/nar/gkr957. PubMed CrossRef Google Scholar

Zebrafish Behavioral Models of Ageing SpringerLink

Clark KJ, Argue DP, Petzold AM, Ekker SC. zfishbook:connecting you to a world of zebrafish revertible mutants. Nucleic Acids Res. 2012;40(D1):D90711. doi:10.1093/nar/gkr957. PubMed CrossRef Google Scholar Zebrafish approaches enhance the translational research Feb 01, 2014 · A number of approaches have been developed to overcome the labor associated with identifying specific genetic mutations resulting from random mutagenesis, including large-scale retroviral insertion approaches.110, 115 The result is a large and growing collection of mutant zebrafish lines, many of which are available for distribution from ZIRC

Zebrafish approaches enhance the translational research

Feb 01, 2014 · A number of approaches have been developed to overcome the labor associated with identifying specific genetic mutations resulting from random mutagenesis, including large-scale retroviral insertion approaches.110, 115 The result is a large and growing collection of mutant zebrafish lines, many of which are available for distribution from ZIRC Zebrafish type I collagen mutants faithfully recapitulate Aug 21, 2018 · Zebrafish with Different Mutations in Type I Collagen Show Variable Skeletal Phenotypes. We systematically analyzed skeletal phenotypes in a large set of zebrafish models carrying different mutations in the zebrafish type I collagen-encoding genes col1a1a, col1a1b, and col1a2 ().As a reference, we also included two knockout mutants, bmp1a / and plod2 /, representing severe

zfishbook:Connecting you to a world of zebrafish

AB - zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. In these lines, a monomeric red fluorescent protein (mRFP) is encoded by an artificial 3 exon, resulting in a translational fusion to endogenous loci. zfishbook:connecting you to a world of zebrafish - COREzfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. In these lines, a monomeric red fluorescent protein (mRFP) is encoded by an artificial 3 exon, resulting in a translational fusion to endogenous loci.

zfishbook:connecting you to a world of zebrafish

zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. In these lines, a monomeric red fluorescent protein (mRFP) is encoded by an artificial 3 0 exon, resulting in a translational fusion to endogenous loci. zfishbook:connecting you to a world of zebrafish Abstract. zfishbook is an internet-based openly accessible database of revertible protein trap gene-breaking transposon (GBT) insertional mutants in the zebrafish, Danio rerio. In these lines, a monomeric red fluorescent protein (mRFP) is encoded by an artificial 3 exon, resulting in a translational fusion to endogenous loci.

zfishbook:Connecting you to a world of zebrafish revertible mutants Article (PDF Available) in Nucleic Acids Research 40(Database issue):D907-11 · November 2011 with 118

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